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. Author manuscript; available in PMC: 2024 Nov 7.
Published in final edited form as: Acc Chem Res. 2023 Oct 26;56(21):3076–3088. doi: 10.1021/acs.accounts.3c00542

Figure 6.

Figure 6.

(A) Structures of 9 and 10. (B) TEM of 9 before (left) and after (right) adding ENTK, bar = 100 nm. (C) Fluorescent images of HeLa cells incubated with 9 for 2 h. (D) Structure of 11 and illustration of the proteolysis (ENTK cleaving off the Flag-tag) of 11 to result in supramolecular assemblies of Nap-ffk(G)y (12) and the consequential phase/morphology transition on mitochondria to facilitate the mitochondrial genetic engineering. (E) Fluorescent images of the HeLa cells incubated with Mito-pGLO plasmid in the presence of 11. Adapted from Ref.47 Copyright ACS 2018 and Ref.51.