(A) Structures of 13 and 14. (B) HRTEM image of nanostructures formed before and after adding ALP to the solution of 13. (C) Western blot analysis of ER-stress marker (Bip, CHOP) after treating HeLa cells with 13 (50 μM) at different time (i.e., 0, 3, 6, 12, 24 or 36 h). (D) Illustration of EISA assemblies to disrupt cell membrane and to target ER and molecular structure of the EISA precursor (13). Adapted from Ref.52 Copyright ACS 2018.