Table 2.

Example of an evidence profile summary of findings given to the evaluators for them to grade in the pilot study. Example question: Should depressed patients in primary care be treated with SSRIs rather than tricyclics?

Outcome	SSRI	tricyclics	Effect		Quality	Relative importance
			Relative (95% CI)	NNT/NNH
Depression Severity	5044 patients	4510 patients	WMD 0.034 (-0.007 to 0.075)	No difference
Transient side effects	1948/7032 (28%)	2072/6334 (33%)	RRR 13% (5% to 20%)	20
Poisoning fatalities*	1/100,000 per year of treatment	58/100,000 per year of treatment	RRR 98%	1754

* Uncertainty about baseline risk: Fatality data may be influenced by which pills are given to whom, and it is uncertain if changing antidepressant would deter suicide attempts