Skip to main content
. Author manuscript; available in PMC: 2024 Dec 15.
Published in final edited form as: J Immunol. 2023 Dec 15;211(12):1767–1782. doi: 10.4049/jimmunol.2300248

Figure 9. LKB1 activated SIK function mediates phosphorylation dependent stabilization of HDAC7 and lineage specific cytokine recall in CD8+ and Th1 cells.

Figure 9.

(A) Model depicting LKB1-SIK mediated phosphorylation dependent stabilization of HDAC7 leading to enhanced HDAC7 nuclear import due to increased HDAC7 protein levels, removal of H3K27Ac marks and restriction of effector cytokine production, epigenetically. (B) Model depicting BioE-1197 mediated inhibition of SIK dependent HDAC7 phosphorylation dependent stabilization which maintains low nuclear HDAC7 levels compared to the control condition, persistence of H3K27Ac levels, and the generation of cells epigenetically poised for enhanced effector cytokine production.