FIG. 6.

Upregulation of the IL-12 receptor in BALB/c mice treated with anti-IL-4. (A) Anti-IL-4 MAb or control antibody was administered to BALB/c mice the day before and at the time of infection, and LN cells were harvested 2 days later for flow-cytometric analysis like that shown in Fig. 2. (B) A representative RPA of an individual mouse, and IFN-γ mRNA quantitation of total LN cells of three BALB/c mice treated as described for panel A. U, uninfected; I+IgG, infected plus treatment with control IgG; I+αIL-4, infected plus treatment with anti-IL-4 antibodies. Infection and treatment are described in Materials and Methods. The value for infected mice treated with anti-IL-4 antibodies is the average of results for two mice.