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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: J Control Release. 2023 Oct 27;364:109–123. doi: 10.1016/j.jconrel.2023.10.028

Figure 7. Schematic depicting the mechanism of efficacy of antioxidant NPs.

Figure 7.

The initial injury to the spinal cord triggers the ROS-medicated progressive degeneration of the spinal cord, resulting in irreversible changes and permanent disability. Treatment with antioxidant NPs inhibits the cascade of degeneration by neutralizing the effect of ROS and their downstream effects on the degeneration of the spinal cord, thus protecting it from secondary injury progression. The treatment creates conditions in the spinal cord microenvironment to promote healing, resulting in improved functional recovery.