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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Drug Alcohol Depend. 2023 Oct 5;253:110987. doi: 10.1016/j.drugalcdep.2023.110987

Figure 1: Withdrawal-like behaviors in mice treated with saline or (2R,6R)-HNK 1-hour before naloxone-induced withdrawal.

Figure 1:

Oxycodone-dependent mice were treated with saline or (2R,6R)-HNK (10 or 30 mg/kg, sc), and the number of (A) paw tremor, (B) rearing, (C) grooming, (D) jumps, (E) hind limb scratching, and (F) writhing events were measured during naloxone-induced withdrawal (n = 16 per group). Data were analyzed via one-way ANOVA followed by Bonferroni post hoc tests. ***P < 0.001. Data are expressed as means (±SEM).