Table 1.
Pooled odds ratios and 95% confidence intervals for associations between tumor characteristics and presence of intraluminal tumor cells
| Characteristics | Presence of intraluminal tumor cells | |||||
|---|---|---|---|---|---|---|
| Absent (n=1,159) |
Present (n=144) | |||||
| No. (%) | No. (%) |
OR (95% CI)a | pb | OR (95% CI)c | pb | |
| Age | 0.01 | 0.002 | ||||
| <55 | 169 (14.6) | 17 (11.8) | 0.96 (0.55, 1.70) | 1.49 (0.79, 2.78) | ||
| 55-64 | 374 (32.3) | 65 (45.1) | 1.68 (1.16, 2.45) | 2.12 (1.40, 3.22) | ||
| ≥65 | 616 (53.2) | 62 (43.1) | 1.00 | 1.00 | ||
| Race d | 0.90 | |||||
| White | 715 (84.3) | 70 (79.6) | 1.00 | --- | ||
| Non-White | 132 (15.6) | 18 (20.5) | 1.15 (0.63, 2.10) | --- | ||
| BMI (kg/m2)e | 0.27 | |||||
| Normal weight (<25) | 277 (23.9) | 33 (22.9) | 1.00 | --- | ||
| Overweight (25-29.9) | 305 (26.3) | 49 (34.0) | 1.38 (0.86, 2.22) | --- | ||
| Obese (≥30) | 546 (47.1) | 56 (38.9) | 0.92 (0.57, 1.47) | --- | ||
| History of Tubal Ligation d,f | 0.50 | |||||
| No | 701 (82.7) | 76 (86.4) | 1.00 | --- | ||
| Yes | 126 (14.9) | 10 (11.4) | 0.67 (0.34, 1.34) | --- | ||
| Intrauterine manipulator use d,g | 0.11 | |||||
| No | 652 (76.9) | 65 (73.9) | 1.00 | --- | ||
| Yes | 178 (21.0) | 18 (20.5) | 0.59 (0.30, 1.18) | --- | ||
| Hysterectomy type | 0.18 | |||||
| Laparoscopic | 373 (32.2) | 37 (25.7) | 1.00 | --- | ||
| Abdominal | 666 (57.5) | 83 (57.6) | 1.20 (0.75, 1.91) | --- | ||
| Other | 120 (10.4) | 24 (16.7) | 1.79 (0.95, 3.36) | --- | ||
| Number of H&E slides reviewed | <0.0001 | <0.0001 | ||||
| 2 | 845 (72.9) | 65 (45.1) | 1.00 | 1.00 | ||
| >2 | 314 (27.1) | 79 (54.9) | 3.41 (2.25, 5.18) | 2.79 (1.81, 4.32) | ||
| Stage | <0.0001 | <0.0001 | ||||
| I | 764 (65.9) | 41 (28.5) | 1.00 | 1.00 | ||
| II | 60 (5.2) | 7 (4.9) | 1.88 (0.81, 4.41) | 2.05 (0.86, 4.90) | ||
| III | 235 (20.3) | 52 (36.1) | 4.04 (2.60, 6.27) | 3.98 (2.48, 6.41) | ||
| IV | 100 (8.6) | 44 (30.6) | 9.36 (5.75, 15.25) | 8.64 (4.97, 15.04) | ||
| Histology | <0.0001 | 0.02 | ||||
| Low-grade endometrioid | 326 (28.1) | 25 (17.4) | 1.00 | 1.00 | ||
| High-grade endometrioid | 248 (21.4) | 28 (19.4) | 1.81 (1.02, 3.21) | 1.09 (0.59, 2.01) | ||
| Serous | 282 (24.3) | 60 (41.7) | 3.95 (2.36, 6.63) | 1.76 (0.96, 3.22) | ||
| Carcinosarcoma | 127 (11.0) | 10 (6.9) | 1.12 (0.52, 2.42) | 0.48 (0.20, 1.11) | ||
| Clear cell | 72 (6.2) | 5 (3.5) | 1.30 (0.48, 3.58) | 0.57 (0.19, 1.74) | ||
| Mixed epithelial | 102 (8.8) | 15 (10.4) | 1.87 (0.94, 3.74) | 0.99 (0.47, 2.12) | ||
| Undifferentiated | 2 (0.2) | 1 (0.7) | 4.84 (0.42, 55.27) | 0.59 (0.05, 7.52) | ||
| LVSI h | <0.0001 | |||||
| Absent | 773 (66.7) | 60 (41.7) | 1.00 | --- | ||
| Present | 379 (32.7) | 84 (58.3) | 2.37 (1.65, 3.41) | --- | ||
| Myometrial invasion | 0.003 | |||||
| <50% | 725 (62.6) | 67 (46.5) | 1.00 | --- | ||
| ≥50% | 434 (37.5) | 77 (53.5) | 1.72 (1.21, 2.45) | --- | ||
Unadjusted ORs and 95% CIs
Wald Chi-Square p-value
ORs and 95% CIs adjusted for age (<55, 55-64, ≥65), FIGO 2009 stage (I, II, III, IV), histology (low-grade endometrioid, high-grade endometrioid, serous, carcinosarcoma, clear cell, mixed epithelial, undifferentiated), number of HE slides reviewed (2, >2), and stratified by site (Ohio State University, Duke University, University of Calgary, Mayo Clinic, University of Pittsburgh)
Unavailable in the University of Calgary dataset and unknown for 1 individual at OSU
Unknown for 37 individuals at University of Calgary
Unknown for 17 individuals at Mayo Clinic; 2 at Ohio State University , 4 at University of Pittsburgh
Unknown for 23 individuals at OSU
Unknown for 7 individuals at University of Calgary