Table 4.

Performance criteria of multivariate models with FIGO 2009 staging and updated staging with ILTC reclassification (overall and stratified by histology), and multivariate models with and without ILTC status (stratified by stage)

Time to recurrence (TTR)					Overall survival (OS)
Performance Metric	FIGO 2009	FIGO 2009 plus ILTCs	Difference	p	Performance Metric	FIGO 2009	FIGO 2009 plus ILTCs	Difference	p
Overall (N=1,303)
AUC for 5-year survival	0.823	0.819	−0.004 (−0.011, 0.003)	0.23	AUC for 5-year survival	0.816	0.816	0.000 (−0.007, 0.008)	0.90
C-statistic	0.492	0.495	0.003 (−0.007, 0.013)	0.55	C-statistic	0.496	0.488	−0.007 (−0.023, 0.008)	0.36
Low-grade endometrioid (N=351)
AUC for 5-year survival	0.909	0.901	−0.008 (−0.065, 0.028)	0.67	AUC for 5-year survival	0.75	0.747	−0.003 (−0.076, 0.079)	0.89
C-statistic	0.543	0.572	0.029 (−0.107, 0.164)	0.68	C-statistic	0.538	0.541	0.003 (−0.123, 0.130)	0.96
High-grade endometrioid (N=276)
AUC for 5-year survival	0.758	0.767	0.009 (−0.033, 0.020)	0.63	AUC for 5-year survival	0.754	0.763	0.009 (−0.035, 0.036)	0.61
C-statistic	0.513	0.509	−0.004 (−0.019, 0.012)	0.63	C-statistic	0.495	0.496	0.001 (−0.029, 0.032)	0.93
Serous (N=342)
AUC for 5-year survival	0.784	0.783	−0.001 (−0.033, 0.028)	0.95	AUC for 5-year survival	0.746	0.745	−0.000 (−0.020, 0.027)	0.98
C-statistic	0.513	0.504	−0.010 (−0.034, 0.015)	0.43	C-statistic	0.534	0.54	0.006 (−0.018, 0.030)	0.64
Carcinosarcoma (N=137)
AUC for 5-year survival	0.8	0.809	0.009 (−0.003, 0.056)	0.33	AUC for 5-year survival	0.812	0.823	0.011 (−0.007, 0.040)	0.25
C-statistic	0.525	0.525	0.000 (0.000, 0.000)	>0.99	C-statistic	0.519	0.486	−0.033 (−0.173, 0.107)	0.64
Mixed epithelial (N=117)
AUC for 5-year survival	0.782	0.775	−0.007 (−0.049, 0.031)	0.62	AUC for 5-year survival	0.717	0.716	−0.001 (−0.032, 0.057)	0.93
C-statistic	0.494	0.522	0.029 (−0.211, 0.268)	0.81	C-statistic	0.532	0.538	0.006 (−0.066, 0.078)	0.86
Clear cell (N=77) a
AUC for 5-year survival	-	-	-	-	AUC for 5-year survival	-	-	-	-
C-statistic	-	-	-	-	C-statistic	-	-	-	-
Performance Metric	Multivariate Model without ILTCs	Multivariate Model with ILTCs	Difference	p	Performance Metric	Multivariate Model without ILTCs	Multivariate Model with ILTCs	Difference	p
Stage I (N=805)
AUC for 5-year survival	0.751	0.745	−0.007 (−0.016, 0.015)	0.5	AUC for 5-year survival	0.751	0.756	0.005 (−0.006, 0.026)	0.53
C-statistic	0.496	0.501	0.004 (−0.009, 0.017)	0.52	C-statistic	0.489	0.496	0.007 (−0.007, 0.021)	0.32
Stage II (N=67)
AUC for 5-year survival	0.615	0.462	−0.153 (−0.259, 0.126)	0.37	AUC for 5-year survival	0.57	0.659	0.089 (−0.073, 0.162)	0.27
C-statistic	0.556	0.562	0.006 (−0.224, 0.236)	0.96	C-statistic	0.618	0.62	0.002 (−0.140, 0.144)	0.98
Stage III (N=287)
AUC for 5-year survival	0.582	0.584	0.003 (−0.013, 0.034)	0.74	AUC for 5-year survival	0.661	0.658	−0.003 (−0.023, 0.043)	0.76
C-statistic	0.536	0.522	−0.014 (−0.061, 0.034)	0.57	C-statistic	0.497	0.497	0.000 (−0.010, 0.010)	>0.99
Stage IV (N=144)
AUC for 5-year survival	0.671	0.598	−0.073 (−0.070, 0.075)	0.54	AUC for 5-year survival	0.715	0.751	0.036 (−0.043, 0.113)	0.34
C-statistic	0.548	0.549	0.002 (−0.021, 0.024)	0.88	C-statistic	0.527	0.529	0.002 (−0.047, 0.050)	0.95

^aNo individuals' stage changed when including ILTC status among cases with clear cell EC; thus, no comparison could be made.