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Fig. 1. Scheme for induction of chromosomal translocation by Cre. Mice containing a loxP site in intron 1 of the ETO gene on chromosome 4 and a loxP site in intron 5 of the AML1-gene on chromosome 16 were crossed to mice expressing Cre recombinase. Interchromosomal site-specific recombination at the loxP sites resulted in Cre-mediated chromosomal translocation [t(4;16), t(16;4)] in the offspring. Filled triangles depict loxP sites.
