Table 11.

In vitro DMPK data for select SLACK inhibitors

No.	cLogPa	% Remaining after 10 minb	Plasma-protein binding (fu)c
5	2.32	<10	0.022
27	2.63	<10	<0.01
43	2.55	58	0.012
58	3.02	59	0.014
60	2.69	<10	0.024
76	3.52	21	<0.01
109	2.55	63	0.012
113	2.82	57	0.012
119	3.05	19	<0.01
121	2.34	71	0.014
122	2.84	26	<0.01

^aCalculated using ChemDraw Professional. Version 16.0.

^bLiver microsomal stability was reported as percent of parent compound remaining after 10 min incubation with NADPH-supplemented mouse liver microsomes.

^cDetermined from DMSO stock solution by equilibrium dialysis in mouse plasma.