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. Author manuscript; available in PMC: 2024 Feb 5.
Published in final edited form as: Nat Neurosci. 2023 Jul 13;26(8):1417–1428. doi: 10.1038/s41593-023-01390-9

Fig. 3 |. Effects of drugs lacking dopamine receptor affinity on behavior and D1-SPN/D2-SPN dynamics.

Fig. 3 |

a, Mean ± s.e.m. locomotor speed during the 15-min recording period after vehicle or drug treatment and the 45-min recording period after amphetamine treatment (****P < 10−4 and *P < 0.05 for comparison to vehicle treatment; ####P < 10−4 and ###P < 10−3 compared to vehicle + amphetamine treatment; one-way ANOVA with Holm–Sidak’s multiple comparison test). b, Mean ± s.e.m. percent PPI, averaged across all pre-pulse intensities after vehicle or high dose of drug + amphetamine treatment (####P < 10−4 and #P < 0.05 compared to vehicle + amphetamine treatment; one-way ANOVA with Holm–Sidak’s multiple comparison test). c, Mean ± s.e.m. D1-SPN and D2-SPN Ca2+ event rates after vehicle or low/high dose of drug + amphetamine treatment, normalized to values after vehicle-only treatment during periods of rest (left) and movement (right). Heat maps depict the ratio of D1-SPN/D2-SPN activity (D1/D2), normalized to the ratio after vehicle-only treatment, or the vehicle-normalized D1-SPN or D2-SPN event rate after vehicle or high dose of drug + amphetamine treatment, normalized to the corresponding value after vehicle + amphetamine treatment (Drug/Amph). d, Mean ± s.e.m. proximal co-activity of D1-SPNs and D2-SPNs after vehicle or low/high dose of drug + amphetamine treatment, normalized to values after vehicle-only treatment during periods of rest (left) and movement (right). Heat maps depict the vehicle-normalized D1-SPN or D2-SPN proximal co-activity after vehicle or high dose of drug + amphetamine treatment, normalized to the corresponding value after vehicle + amphetamine treatment. ***P < 10−3 compared to vehicle treatment; ####P < 10−4, ###P < 10−3, ##P < 10−2 and #P < 0.05 compared to vehicle + amphetamine treatment; one-way ANOVA with Holm–Sidakʼs multiple comparison test.