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. Author manuscript; available in PMC: 2024 Feb 5.
Published in final edited form as: Nat Neurosci. 2023 Jul 13;26(8):1417–1428. doi: 10.1038/s41593-023-01390-9

Extended Data Fig. 2 |. Antipsychotic drug dose selection based on locomotor activity.

Extended Data Fig. 2 |

a–c, Locomotor activity in untethered, C57BL6/J mice during 15 min following vehicle or drug treatment and 45 min following amphetamine treatment (see Fig. 2a). Effects of haloperidol, olanzapine, clozapine, or MP-10 (a), xanomeline, VU0467154, or SEP-363856 (b), and SKF39393, SCH23390, or SCH39166 (c) on baseline and amphetamine-driven locomotion. The ‘low’ and ‘high’ doses we subsequently used for Ca2+ imaging experiments are indicated in red. Data are expressed as mean ± s.e.m. (****P < 10−4 ***P < 10−3, **P < 10−2 and *P < 0.05 for comparison to vehicle treatment; ####P < 10−4 and ##P < 10−2 compared to vehicle + amphetamine treatment; One-way ANOVA with Holm-Sidak’s multiple comparison test).