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. Author manuscript; available in PMC: 2024 Nov 2.
Published in final edited form as: Cell Stem Cell. 2023 Oct 20;30(11):1403–1420. doi: 10.1016/j.stem.2023.09.013

Figure 3. Antagonistic pleiotropy of HSC features during young adulthood and old age.

Figure 3.

Many features of HSCs, such as pro-survival mechanisms, stress response mechanisms, quiescence, cellular memory, and response to niche factors, are beneficial for optimal HSC function and response to organismal demands in young adulthood but become detrimental and maladaptive during aging.