Table I –

Described Roles of Ets1 in Mature B cells

B Cell Roles of Ets1 Described in vivo in Mice	Reference(s)
Loss of marginal zone type B cells *	(Eyquem et al., 2004; Sunshine et al., 2019; Wang et al., 2005)
Increased expression of activation markers	(Sunshine et al., 2019; Wang et al., 2005)
Increased differentiation to germinal center B cells	(Russell et al., 2015)
Increased differentiation to memory B cells *	(Sunshine et al., 2019)
Increased differentiation to plasmablasts/plasma cells *	(Barton et al., 1998; Bories et al., 1995; John et al., 2014; Luo et al., 2014; Sunshine et al., 2019)
Increased secretion of autoantibodies *	(Mouly et al., 2010; Sunshine et al., 2019; Wang et al., 2005)
Loss of peripheral tolerance to self-antigens	(Russell et al., 2015)
Increased secretion of IgM *	(Barton et al., 1998; Bories et al., 1995; Mouly et al., 2010; Nguyen et al., 2012; Sunshine et al., 2019)
Increased class-switching to IgG1 and IgE	(Mouly et al., 2010; Nguyen et al., 2012; Sunshine et al., 2019)
Decreased class-switching to IgG2a	(Nguyen et al., 2012)

^*Functions marked by asterisks are known to be (at least in part) B cell-intrinsic