Table II –

Described Roles of Ets1 in Mature CD4+ T cells

T Cell Roles of Ets1 Described in vivo in Mice	Reference(s)
Reduced numbers of peripheral T cells	(Bories et al., 1995; Clements et al., 2006)
Reduced expression of CD5, Thy1 and CD127	(Bories et al., 1995; Clements et al., 2006; Mouly et al., 2010)
Reduced numbers of Tregs and reduced FoxP3 levels	(Mouly et al., 2010)
Skewing towards memory phenotype (CD44+) *	(Clements et al., 2006; Kim et al., 2018)
Decreased production of IL-2	(Grenningloh et al., 2005; Nagaleekar et al., 2008)
Decreased differentiation to Th1 and Th2 cells	(Grenningloh et al., 2005)
Increased differentiation to Tfh2 cells *	(Kim et al., 2018)
Increased differentiation to Th17 cells	(Moisan et al., 2007)

^*Functions marked by asterisks are known to be T cell-intrinsic