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. Author manuscript; available in PMC: 2024 Feb 5.
Published in final edited form as: Chem Rev. 2021 Oct 12;122(8):7415–7441. doi: 10.1021/acs.chemrev.1c00377

Figure 12.

Figure 12.

CDMS analysis of classical vaccines. (a) Mass spectrum measured by CDMS for IPOL vaccine. The expected masses of the C- and D-antigen particles (see text) are shown by the purple and green lines, respectively. The bin size is 20 kDa. (b) Charge spectra of IPOL (black) and the AAV8 reference standard (red). The bin size is 1 e. (c) Structure of the triple-layered rotavirus. (d) Mass spectrum measured by CDMS for the RotaTeq vaccine. Colored vertical lines show expected masses of the DLP with all pentonal trimers (blue) and the DLP with all pentonal trimers but missing the genome (green). The bin size is 100 kDa. (a, b, d) Adapted with permission from ref 239. Copyright 2021 American Chemical Society. (c) Adapted with permission from ref 244. Copyright 2014 Elsevier under Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License (CC By-NC-ND 3.0) https://creativecommons.org/licenses/by-nc-nd/3.0/legalcode.