Table 1.

Disease severity metrics for influenza-infected mice in thermostress housing.

Housing	Thermostress
Diet	CD		HFD
Sex	Male	Female	Male	Female
Weight loss (g)	6.983 ± 0.35	4.741 ± 0.26	6.750 ± 0.38	4.920 ± 0.34
Left lung weight (mg)	106.1 ± 8.55	95.93 ± 4.01	149.9 ± 5.85*	147.9 ± 8.62†
M protein (Ct Value)	20.00 ± 0.50	22.35 ± 1.01	21.74 ± 0.51	20.00 ± 0.36
BALF IL-6 (ng/mL)	1.450 ± 0.08	1.410 ± 0.21	5.231 ± 0.53†	2.627 ± 0.25
Lung CD45+ cells (# × 106)	1.876 ± 0.481	1.410 ± 0.126	2.924 ± 0.174‡	1.225 ± 0.0874
Lung macrophage (# × 105)	6.063 ± 0.451	4.822 ± 0.514	15.74 ± 1.61†	6.764 ± 0.535
Lung neutrophil (# × 104)	6.713 ± 0.787	8.664 ± 1.71	25.12 ± 3.21*	7.304 ± 0.925

All conditions reported as mean ± standard error of the mean (SEM). Ordinary one-way analysis of variance, statistical analysis compares HFD mice and their respective CD sex control (HFD male vs. CD male, HFD female vs. CD female).

# = number; BALF = bronchoalveolar lavage fluid; CD = chow diet; HFD = high-fat diet; IL-6 = interleukin-6.

^‡p < 0.01.

^†p < 0.0001.

^*p < 0.001.