Table 2.

Disease severity metrics for influenza-infected mice in thermoneutral housing.

Housing	Thermoneutral
Diet	CD		HFD
Sex	Male	Female	Male	Female
Weight loss (g)	6.956 ± 0.12	5.949 ± 0.42	7.050 ± 0.18	6.328 ± 0.28
Left lung weight (mg)	118.9 ± 6.34	114.3 ± 3.92	150.3 ± 9.40*	136.3 ± 6.08*
M protein (Ct Value)	23.36 ± 0.50	20.92 ± 0.54	23.03 ± 0.49	21.44 ± 0.54
BALF IL-6 (ng/mL)	1.526 ± 0.24	1.632 ± 0.20	4.905 ± 1.07†	3.556 ± 0.61*
Lung CD45+ cells (# × 106)	0.9057 ± 0.118	1.412 ± 0.123	2.177 ± 0.373†	2.469 ± 0.270†
Lung macrophage (# × 105)	5.087 ± 0.916	7.520 ± 0.680	13.18 ± 2.63†	14.15 ± 1.69†
Lung neutrophil (# × 104)	9.250 ± 1.49	7.266 ± 0.890	19.93 ± 3.95*	16.30 ± 2.41†

All conditions reported as mean ± standard error of the mean (SEM). Ordinary one-way analysis of variance, statistical analysis compares HFD mice and their respective CD sex control (HFD male vs. CD male, HFD female vs. CD female).

# = number; BALF = bronchoalveolar lavage fluid; CD = chow diet; HFD = high-fat diet; IL-6 = interleukin-6.

^*p < 0.05.

^†p < 0.01.