Table 1.
Genes causing dilated cardiomyopathy
| Gene | Gene symbol | Mode of inheritance | Classificationa |
|---|---|---|---|
| ATP Binding Cassette Subfamily C Member 9 | ABCC9 | AD | Limited |
| Actin Alpha Cardiac Muscle 1 | ACTCI | AD | Moderate |
| Ankyrin Repeat Domain 1 | ANKRDI | AD | Limited |
| BAG Cochaperone 3 | BAG3 | AD | Definitive |
| Cysteine And Glycine Rich Protein 3 | CSRP3 | AD | Limited |
| Cardiotrophin 1 | CTFI | AD | Limited |
| Desmin | DES | AD | Definitive |
| Desmoglein 2 | DSG2 | AD | Limited |
| Desmoplakin | DSP | AD | Definitiveb |
| Dystrobrevin Alpha | DTNA | AD | Limited |
| EYA Transcriptional Coactivator And Phosphatase 4 | EYA4 | AD | Limited |
| Filamin C | FLNC | AD | Definitive |
| GATA Zinc Finger Domain Containing 1 | GATADI | AR | Limited |
| Integrin Linked Kinase | ILK | AD | Limited |
| Junctophilin 2 | JPH2 | AR | Moderate |
| Laminin Subunit Alpha 4 | LAMA4 | AD | Limited |
| LIM Domain Binding 3 | LDB3 | AD | Limited |
| Lamin A/C | LMNA | AD | Definitive |
| Leucine Rich Repeat Containing 10 | LRRC10 | AR | NKDR/AMO |
| MIB E3 Ubiquitin Protein Ligase 1 | MIB1 | AD | NKDR/AMO |
| Myosin Binding Protein C 3 | MYBPC3 | AD | Limited |
| Myosin Heavy Chain 6 | MYH6 | AD | Limited |
| Myosin Heavy Chain 7 | MYH7 | AD | Definitive |
| Myosin Light Chain 2 | MYL2 | AD | Limited |
| Myosin Light Chain 3 | MYL3 | AD | Disputed |
| Myopalladin | MYPN | AD | Limited |
| Nebulette | NEBL | AD | Limited |
| Nexilin F-Actin Binding Protein | NEXN | AD | Moderate |
| NK2 Homeobox 5 | NKX2–5 | AD | Limited |
| Natriuretic Peptide A | NPPA | AR | NKDR |
| Obscurin | OBSCN | AD | Limited |
| PDZ And LIM Domain 3 | PDLIM3 | AD | Disputed |
| Phospholamban | PLN | AD | Moderateb |
| Plakophillin 2 | PKP2 | AD | Disputed |
| Pleckstrin Homology And RUN Domain Containing M2 | PLEKHM2 | AR | Limited |
| PR/SET Domain 16 | PRDM16 | AD | Limited |
| Presenilin 1 | PSEN1 | AD | Disputed |
| Presenilin 2 | PSEN2 | AD | Limited |
| RNA Binding Motif Protein 20 | RBM20 | AD | Definitive |
| Sodium Voltage-Gated Channel Alpha Subunit 5 | SCN5A | AD | Definitive |
| Sarcoglycan Delta | SGCD | AD | Limited |
| T-Box Transcription Factor 20 | TBX20 | AD | Limited |
| Titin-Cap | TCAP | AD | Limited |
| Transmembrane Protein 43 | TMEM43 | AD | Definitiveb |
| Troponin C1, Slow Skeletal And Cardiac Type | TNNC1 | AD | Definitive |
| Troponin I3, Cardiac Type | TNNI3 | AD | Moderate |
| TNNI3 Interacting Kinase | TNNI3K | AD | Limited |
| Troponin T2, Cardiac Type | TNNT2 | AD | Definitive |
| Tropomyosin 1 | TPM1 | AD | Moderate |
| Titin | TTN | AD | Definitive |
| Vinculin | VCL | AD | Moderate |
b
In arrhythmogenic right ventricular cardiomyopathy.
Abbreviations: AD, autosomal dominant; AMO, animal model only; AR, autosomal recessive; NKDR, no known disease relationship.