Skip to main content
. Author manuscript; available in PMC: 2025 Feb 1.
Published in final edited form as: Exp Neurol. 2023 Nov 22;372:114615. doi: 10.1016/j.expneurol.2023.114615

Fig. 12.

Fig. 12

Mechanism representation in mast cells after GMH. GMH induces FcεRI/Syk activation thus leading to an increase in degranulation of chymase and tryptase and producing a neuroinflammatory response. Administration of GW0742 activates PPARβ/δ, CD300a and phosphorylated SHP1, thus inhibiting FcεRI/Syk signaling and reducing inflammation. Administration of PPARβ/δ and CD300a siRNA reduce the effects of GW0742/PPARβ/δ/CD300a/SHP1 thus reducing the beneficial effects of GW0742 on GMH-induced inflammation.