Table 1:

Subject Demographics

	control (N=693)	CRC (N=701)	Overall (N=1394)
Study name (country)
FengQ_2015 (AUT)	61 (8.8%)	46 (6.6%)	107 (7.7%)
GuptaA_2019 (IND)	30 (4.3%)	30 (4.3%)	60 (4.3%)
HanniganGD_2017 (USA&CAN)	28 (4.0%)	27 (3.9%)	55 (3.9%)
ThomasAM_2018a (ITA)	24 (3.5%)	29 (4.1%)	53 (3.8%)
ThomasAM_2018b (ITA)	27 (3.9%)	32 (4.6%)	59 (4.2%)
ThomasAM_2019_c (JPN)	40 (5.8%)	40 (5.7%)	80 (5.7%)
VogtmannE_2016 (USA)	52 (7.5%)	52 (7.4%)	104 (7.5%)
WirbelJ_2018 ((DEU)	65 (9.4%)	60 (8.6%)	125 (9.0%)
YachidaS_2019 (JPN)	251 (36.2%)	258 (36.8%)	509 (36.5%)
YuJ_2015 (CHN)	54 (7.8%)	74 (10.6%)	128 (9.2%)
ZellerG_2014 (FRA)	61 (8.8%)	53 (7.6%)	114 (8.2%)
Age
Mean (SD)	60.2 (12.3)	63.3 (11.0)	61.8 (11.7)
Median [Min, Max]	63.0 [21.0, 84.0]	64.0 [28.0, 90.0]	64.0 [21.0, 90.0]
Age category
<50	125 (18.0%)	82 (11.7%)	207 (14.8%)
50-65	277 (40.0%)	278 (39.7%)	555 (39.8%)
>65	291 (42.0%)	341 (48.6%)	632 (45.3%)
Gender
female	310 (44.7%)	257 (36.7%)	567 (40.7%)
male	383 (55.3%)	444 (63.3%)	827 (59.3%)
BMI
Mean (SD)	24.1 (3.73)	24.3 (4.31)	24.2 (4.03)
Median [Min, Max]	23.5 [16.4, 39.3]	23.8 [13.3, 57.5]	23.6 [13.3, 57.5]
Missing	5 (0.7%)	9 (1.3%)	14 (1.0%)