Table 3.
Animals PODs and their HED.
| Compounds | Species3 | LOAEL (mg/kg) | DAF | Unadjusted HED (mg) | UF | HED (mg) |
|---|---|---|---|---|---|---|
| Thalidomide1 | Rat | 50 | 0.247 | 828.9 | 30 | 27.63 |
| Rabbit | 60 | 0.478 | 1924 | 30 | 64.13 | |
| Carbamazepine2 | Rat | 400 | 0.247 | 6631 | 30 | 221 |
| Rabbit | 225 | 0.478 | 7215 | 30 | 241 |
1
Findings are abortions in rats and decreased number of fetuses, increased resorption in rabbits.
2
Findings are decreased implantation sites in rats and resorption in rabbits.
3
Rat, rabbit, and human body weight were 0.25, 3.5 and 67.1kg, respectively.