Table 3.
Effect of EtOH exposure on action potential parameters of anteroventral thalamic nuclei neurons
| Injected current (pA) | Females | Males | Significant P Values | |||
|---|---|---|---|---|---|---|
| Control (n) | EtOH (n) | Control (n) | EtOH (n) | |||
| Threshold | 200 | −39.43 ± 0.94 (5) | −35.78 ± 3.61 (8) | 34.51 ± 4.01 (6) | 35.45± 4.20 (5) | <0.0001 (Injected current) |
| 400 | −37.16 ± 1.48 (7) | −36.77 ± 2.91 (9) | −36.59 ± 1.57 (9) | −36.95± 1.67 (6) | ||
| 600 | −33.61 ± 1.07 (7) | −35.04 ± 2.05 (9) | −34.24 ± 1.99 (10) | −33.12± 1.92 (10) | ||
| 800 | −30.22 ± 0.86 (7) | −32.26 ± 2.08 (9) | −31.45 ± 1.61 (10) | −29.58± 1.58 (10) | ||
| 1000 | −28.23 ± 0.77 (7) | −29.58 ± 1.62 (9) | −31.28 ± 2.53 (10) | −27.94± 1.66 (10) | ||
| Number/ 500 ms pulse | 200 | 1.33 ± 0.43 (7) | 1.83 ± 0.47 (9) | 0.96 ± 0.34 (10) | 0.85 ± 0.29 (10) | <0.0001 (Sex) <0.0001 (injected current) 0.036 (Sex x Treatment) 0.033 (Sex x Current) |
| 400 | 4.11 ± 2 (6) | 9.94 ± 3.13 (9) | 3.11 ± 0.73 (9) | 1.6 ± 0.54 (10) | ||
| 600 | 29.14 ± 9.49 (7) | 36.83 ± 10.63 (9) | 25.18 ± 5.58 (10) | 17.2 ± 6.26 (10) | ||
| 800 | 52.80 ± 12.53 (7) | 55.33 ± 10.35 (9) | 52.78 ± 7.37 (10) | 40.4 ± 8.63 (10) | ||
| 1000 | 72.71 ± 9.21 (7) | 77.22 ± 7.66 (9) | 49.92 ± 9.89 (9) | 54.1 ± 10.35 (10) | ||
| Overshoot amplitude (mV) | 200 | 14.49 ± 4.05 (7) | 16.10 ± 2.74 (9) | 10.51 ± 3.25 (10) | 8.19 ± 3.32 (10) | <0.0001 (Injected current) |
| 400 | 18.17 ± 2.32 (7) | 20.41 ± 1.59 (9) | 19.69 ± 1.13 (9) | 12.94 ± 3.87 (10) | ||
| 600 | 20.07 ± 1.46 (6) | 20.43 ± 0.98 (9) | 19.38 ± 1.56 (10) | 22.38 ± 1.54 (10) | ||
| 800 | 17.45 ± 1.98 (7) | 20.79 ± 1.19 (9) | 17.00 ± 2.84 (10) | 21.95 ± 1.55 (10) | ||
| 1000 | 15.48 ± 1.93 (7) | 19.21 ± 1.40 (9) | 15.66 ± 2.30 (10) | 20.66 ± 1.45 (10) | ||
| Adaptation index | 1000 | 0.42 ± 0.028 (7) | 0.48 ± 0.056 (9) | 0.44 ± 0.05 (8) | 0.47 ± 0.040 (8) | |
| After-hyperpolarization amplitude (mV) | 200 | −5.09 ± 1.079 (7) | −6.43 ± 1.69 (9) | −6.29 ± 0.93 (10) | −5.96 ± 1.15 (10) | <0.0001 (Injected current) |
| 400 | −6.58 ± 1.34 (7) | −8.68 ± 1.64 (9) | −9.08 ± 1.27 (10) | −8.05 ± 1.63 (10) | ||
| 600 | −7.18 ± 1.36 (7) | −9.26 ± 1.50 (9) | −9.87 ± 1.31 (10) | −8.61 ± 1.49 (10) | ||
| 800 | −7.38 ± 1.31 (7) | −9.97 ± 1.83 (9) | −9.99 ± 1.4 (10) | −9.13 ± 1.49 (10) | ||
| 1000 | −10.88 ± 3.25 (7) | −13.657 ± 2.62 (9) | −16.88 ± 3.56 (10) | −11.11 ± 2.01 (10) | ||
For more details of statistical analysis, see Supplementary Table. Numbers in parenthesis represent the number of animals from the following number of litters: control female = 5 litters; EtOH female = 6 litters; control male = 8 litters; EtOH male = 5 litters.