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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Kidney Int. 2023 Sep 30;104(6):1150–1163. doi: 10.1016/j.kint.2023.09.013

Figure 6: HNF4α activity mirrors QPRT activity.

Figure 6:

a. In human kidney snRNASeq, PGC1α is ubiquitously expressed, but HNF4α localizes to the proximal tubule. b. De novo NAD+ biosynthesis and QPRT also localize to the proximal tubule (left of dotted line), while enzymes of other NAD+ biosynthetic pathways are expressed throughout the kidney. c. After cisplatin, the degree of QPRT suppression correlates with HNF4α suppression in mouse kidneys. d. Overexpressing HNF4α (OE) increases QPRT expression. HNF4α OE increases NAD+, while siHNF4a decreases NAD+ in the cytoplasmic (e) nuclear (f), and mitochondrial (g) compartments. h. HNF4α OE increases ATP, and siHNF4α decreases ATP (I). * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.