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. Author manuscript; available in PMC: 2024 Dec 1.
Published in final edited form as: Kidney Int. 2023 Sep 30;104(6):1150–1163. doi: 10.1016/j.kint.2023.09.013

Figure 7: HNF4α modulates renal QPRT, connecting PGC1α to de novo NAD+ biosynthesis.

Figure 7:

a. QPRT qPCR of HNF4α ChIP confirms that HNF4α does enrich at the QPRT locus in kidney tissue. b. In iNephPGC1α mice, PGC1α overexpression increases HNF4α enrichment at QPRT, and (c) the level of enrichment correlates with the degree of PGC1α overexpression. d. siHNF4α abrogates the PGC1α mediated increase in QPRT expression. * = p<0.05, ** = p<0.01, *** = p<0.001, **** = p<0.0001.