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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: J Cyst Fibros. 2023 Sep 12;22(6):1113–1119. doi: 10.1016/j.jcf.2023.09.002

Figure 1.

Figure 1.

Representative NPD tracings showing PD after serial administration of 1) amiloride (100 μM), 2)Cl− free forskolin (20 μM), 3)INH-172 (10 μM) and GlyH-101 (10 μM), and 4) UTP (150 μM) (A), followed by summary data (B) in RGAE-treated and control CF rats. RGAE treatment caused NPD hyper-polarization with UTP (control = −5.96 +/− 2.3 mV, RGAE = −12.51 +/− 1.04 mV, p <0.05; unpaired t test), indicating potentiation of UTP-mediated Cl− secretion through TMEM16A.