Table 2.

Pathway enrichment analysis

Subpathway	Domain	Hypergeometric P Value
		Baseline	Longitudinal	NiCK
Acyl cholines	Intelligence	0	0	—
γ-Glutamyl amino acids		0.008	—	<0.001
Androgenic steroids	Attention regulation	0.002	<0.001	—
Tryptophan		0.02	—	0.05
Dicarboxylates	Working memory	0.002	0.01	—
Glycine, serine, and threonines		0.01	—	0.02
Lysines		—	0.01	0.02
Tryptophan		0.005	0.02	—
Dicarboxylates	Executive function	—	0.03	0.05
Dihydrosphingomyelins		<0.001	<0.001	—
Vitamin A	Executive function, non–eGFR-adjusted	0.01	—	0.003
Acetylated peptides		0.003	0.003	—
Alanine and aspartate		0.03	0.02	—
Aminosugars		0.03	0.002	—
Polyamines		0.03	<0.001	—
Purine and adenines		0.05	0.04	—
Sterols		0.05	0.04	—

Hypergeometric distribution tests identified metabolite subpathways associated with neurocognitive domain z-scores in at least two of three analytic groups. Tryptophan and γ-glutamyl amino acid metabolite associations were externally replicated in NiCK. “—” denotes subpathways that did not replicate in the sample. NiCK, Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease.