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. 2005 Apr 22;33(7):2310–2317. doi: 10.1093/nar/gki526

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Agarose gel electrophoresis showing the effect of radicicol (a) and geldanamycin (b) on decatenation of kDNA by the DNA topoisomerase VI. Lane 1, linear kDNA marker (L); lane 2, decatenated kDNA marker: nicked, open circular (N) and relaxed DNA (R); lane 3, catenated kDNA (C); lane 4, kDNA with Topo VI; lane 5, kDNA with Topo VI and DMSO; and lanes 6–11, kDNA with Topo VI in the presence of radicicol or geldanamycin (250, 200, 125, 100, 50 and 25 μM, respectively).