TABLE 3.

Sensitivity analyses with statistical adjustment for liver disease severity on the associations between problematic drinking and LDQoL scores (n=310)

	Overall LDQoL		LDQoL Health distress		LDQoL Memory/concentration
	b (95% CI)	p	b (95% CI)	p	b (95% CI)	p
Problematic drinking
AUDIT≥8 vs.<8	−5.71 (−10.69, −0.72)	0.03	−8.77 (−17.50, −0.04)	0.049	−9.79 (−17.86, −1.71)	0.02
Age (y)	0.07 (−0.14, 0.27)	0.54	0.39 (0.02, 0.75)	0.04	−0.03 (−0.37, 0.31)	0.85
Sex
Female vs. male	−5.36 (−11.00, 0.28)	0.06	−10.55 (−20.42, −0.68)	0.04	−0.71 (−9.84, 8.43)	0.88
Race/ethnicity
Latino vs. White	3.36 (−1.28, 8.00)	0.16	5.31 (−2.81, 13.44)	0.20	−0.83 (−8.35, 6.69)	0.83
Other vs. White	4.46 (−0.34, 9.27)	0.07	5.98 (−2.44, 14.40)	0.16	3.40 (−4.38, 11.18)	0.39
Site
PAVA vs. ZSFG	−5.91 (−11.29, −0.53)	0.03	−10.66 (−20.08, −1.24)	0.03	−8.84 (−17.56, −0.12)	0.047
SFVA vs. ZSFG	0.68 (−5.22, 6.59)	0.82	0.57 (−9.78, 10.92)	0.91	−3.71 (13.27, 5.86)	0.45
Pandemic-related stress (points)	−3.52 (−4.97, −2.07)	<0.001	−5.74 (−8.27, −3.20)	<0.001	−3.49 (−5.83, −1.14)	0.004
History of anxiety or depressive disorder	−5.07 (−9.38, −0.76)	0.02	−3.37 (−10.92, 4.18)	0.38	−4.34 (−11.33, 2.64)	0.22
MELD-Na Score	−0.27 (−0.70, 0.17)	0.23	−0.46 (−1.23, 0.30)	0.23	0.24 (−0.46, 0.94)	0.50
Decompensated cirrhosis
Current	−5.91 (−11.07, −0.75)	0.03	−9.82 (−18.85, −0.79)	0.03	−3.97 (−12.33, 4.38)	0.35
Prior	−2.93 (−8.01, 2.15)	0.26	−14.10 (−22.99, −5.21)	0.002	−3.84 (−12.07, 4.38)	0.36

Note: Higher LDQoL scores reflect better QoL. Lower LDQoL scores reflect worse QoL.

Abbreviations: AUDIT, Alcohol Use Disorders Identification Test; LDQoL, liver disease quality of life; MELD-Na, Model for End-Stage Liver Disease-Sodium; PAVA, Palo Alto Veterans Affairs Health Care System; SFVA, San Francisco Veterans Affairs Health Care System; ZSFG, Zuckerberg San Francisco General Hospital.