Table 2.
Differences between the Profiles of the Study Drug Dose Response Curves
| Outcome Variable | P value | |
| Nociception Tests | ||
| Electrical pain threshold | <0.01 | * |
| Pressure pain threshold | <0.01 | * |
| Heat pain threshold | 0.99 | |
| Skin temperature | 0.59 | |
| Sedation Score | ||
| Subjective sedation visual analogue score | 0.01 | * |
| OASS | <0.01 | * |
| Psychometric Tests | ||
| SDMT | 0.03 | * |
| SDMT errors | 0.17 | |
| SDMT recall | 0.99 | |
| Reaction time | <0.01 | * |
| Finger tapping test | <0.01 | * |
| Physiological Tests | ||
| Systolic blood pressure | 0.34 | |
| Diastolic blood pressure | 0.99 | |
| Heart rate | 0.99 | |
| Respiratory rate | 0.99 | |
| Tidal volume | 0.73 | |
| Pulse oximetry | 0.99 | |
| End tidal carbon dioxide | 0.99 | |
| Minute volume | 0.99 | |
SDMT denotes symbol digit modalities test; OASS, observer assessment of alertness/sedation scale; *, P ≤ 0.05