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. 2024 Feb 5;19(2):e0296653. doi: 10.1371/journal.pone.0296653

Table 2. Univariable and multivariable Cox proportional hazards regression of measles immunity.

Univariable Cox Regression Multivariable Cox Regression
N HR 95% CI p-value HR 95% CI p-value
Diagnosis
    Metabolic disease 20
    Biliary/cholestatic disease 69 1.26 0.74, 2.17 0.394
    Malignant liver disease 16 1.21 0.52, 2.83 0.653
    Acute liver failure 13 0.66 0.30, 1.47 0.309
    Cryptogenic cirrhosis/others 7 1.03 0.38, 2.78 0.952
Sex
    Female 57
    Male 68 0.67 0.44, 1.01 0.058 1.24 0.76, 2.02 0.38
Living related donation
    No 108
    Yes 17 0.63 0.32, 1.25 0.186 1.06 0.46, 2.43 0.90
Type of graft
    Split graft 81
    Whole graft 44 1.13 0.75, 1.72 0.558
Age at transplantation in years 125 0.94 0.89, 1.00 0.044 1.07 0.97, 1.18 0.19
Vaccinations prior to transplantation
    1 vaccine dose 31
    2 vaccines doses 94 1.43 0.81, 2.51 0.200 4.30 2.09, 8.83 <0.001
Age at 1st vaccination in years 125 1.16 0.99, 1.35 0.070 11.5 6.92, 19.1 <0.001
Age at 1st vaccination below 1 year
    No 67
    Yes 58 1.04 0.69, 1.57 0.854
Seroprevalence at time of transplantation
    No 23
    Yes 102 2.26 1.13, 4.50 0.021 2.38 1.07, 5.30 0.034
Age at testing in years 125 0.31 0.25, 0.40 <0.001 0.09 0.06, 0.15 <0.001
Biopsy proven acute rejection (RAI-Score≥3)
    No 76
    Yes 49 0.98 0.64, 1.49 0.913
Immunosuppression
    Cyclosporine A 14
    Tacrolimus 111 1.63 0.79, 3.38 0.186 1.43 0.62, 3.32 0.40
Intensified immunosuppression
    No 101
    Yes 24 1.52 0.94, 2.46 0.090 1.08 0.58, 2.00 0.81