Table 2. Univariable and multivariable Cox proportional hazards regression of measles immunity.
| Univariable Cox Regression | Multivariable Cox Regression | ||||||
|---|---|---|---|---|---|---|---|
| N | HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Diagnosis | |||||||
| Metabolic disease | 20 | — | — | ||||
| Biliary/cholestatic disease | 69 | 1.26 | 0.74, 2.17 | 0.394 | |||
| Malignant liver disease | 16 | 1.21 | 0.52, 2.83 | 0.653 | |||
| Acute liver failure | 13 | 0.66 | 0.30, 1.47 | 0.309 | |||
| Cryptogenic cirrhosis/others | 7 | 1.03 | 0.38, 2.78 | 0.952 | |||
| Sex | |||||||
| Female | 57 | — | — | — | — | ||
| Male | 68 | 0.67 | 0.44, 1.01 | 0.058 | 1.24 | 0.76, 2.02 | 0.38 |
| Living related donation | |||||||
| No | 108 | — | — | — | — | ||
| Yes | 17 | 0.63 | 0.32, 1.25 | 0.186 | 1.06 | 0.46, 2.43 | 0.90 |
| Type of graft | |||||||
| Split graft | 81 | — | — | ||||
| Whole graft | 44 | 1.13 | 0.75, 1.72 | 0.558 | |||
| Age at transplantation in years | 125 | 0.94 | 0.89, 1.00 | 0.044 | 1.07 | 0.97, 1.18 | 0.19 |
| Vaccinations prior to transplantation | |||||||
| 1 vaccine dose | 31 | — | — | — | — | ||
| 2 vaccines doses | 94 | 1.43 | 0.81, 2.51 | 0.200 | 4.30 | 2.09, 8.83 | <0.001 |
| Age at 1st vaccination in years | 125 | 1.16 | 0.99, 1.35 | 0.070 | 11.5 | 6.92, 19.1 | <0.001 |
| Age at 1st vaccination below 1 year | |||||||
| No | 67 | — | — | ||||
| Yes | 58 | 1.04 | 0.69, 1.57 | 0.854 | |||
| Seroprevalence at time of transplantation | |||||||
| No | 23 | — | — | — | — | ||
| Yes | 102 | 2.26 | 1.13, 4.50 | 0.021 | 2.38 | 1.07, 5.30 | 0.034 |
| Age at testing in years | 125 | 0.31 | 0.25, 0.40 | <0.001 | 0.09 | 0.06, 0.15 | <0.001 |
| Biopsy proven acute rejection (RAI-Score≥3) | |||||||
| No | 76 | — | — | ||||
| Yes | 49 | 0.98 | 0.64, 1.49 | 0.913 | |||
| Immunosuppression | |||||||
| Cyclosporine A | 14 | — | — | — | — | ||
| Tacrolimus | 111 | 1.63 | 0.79, 3.38 | 0.186 | 1.43 | 0.62, 3.32 | 0.40 |
| Intensified immunosuppression | |||||||
| No | 101 | — | — | — | — | ||
| Yes | 24 | 1.52 | 0.94, 2.46 | 0.090 | 1.08 | 0.58, 2.00 | 0.81 |