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. 2005 Apr 7;5:7. doi: 10.1186/1471-2377-5-7

Figure 1.

Figure 1

The composition of mononucleate cells was altered in Lama2-/- and mdx diseased muscles compared to healthy muscles. Mononucleate cells were prepared from muscles of Lama2-/- (3 week old), mdx (7.5 weeks old), and age- and strain-matched control mice and analyzed by FACS for expression of Sca-1 and CD45. A. Scatter-plots of a representative FACS study of the different cell subsets defined by Sca-1 and CD45 expression patterns in normal C57BL/10ScSn (left) and mdx (right) muscles. B. Scatter-plots of a representative FACS study of the different cell subsets in normal C57BL/6J (right) and Lama2-/- (left) muscles. Significant differences were observed in the distribution of cells between the wild type and disease conditions (see Fig. 2 and Table 1 for quantitative and statistical analyses). As also noted in the text, mdx muscles contained several-fold more mononucleate cells per gram of tissue than Lama2-/- muscles.