Table 1.
Baseline characteristics of ISCHEMIA Biorepository Biomarker Cohort
| Characteristic | Study Population No. (%)a |
|---|---|
| No. | 757 |
| Demographics | |
| Age at randomization, years | |
| No. | 757 |
| Median (Q1, Q3) | 67 (61, 72) |
| Follow-up time, years | |
| No. | 757 |
| Median (Q1, Q3) | 3 (2, 5) |
| Female sex | 144/757 (19%) |
| Race | |
| White | 634/755 (84%) |
| Black | 84/755 (11%) |
| Asian | 20/755 (3%) |
| Other or multiple ethnic groups | 17/755 (2%) |
| Hispanic or Latino ethnicity | 38/750 (5%) |
| Cigarette smoking | |
| Current smoker | 85/757 (11%) |
| Former smoker | 412/757 (54%) |
| Never smoker | 260/757 (34%) |
| Randomized to invasive | 368/757 (49%) |
| Randomized to conservative | 389/757 (51%) |
| Clinical history | |
| Diabetes | 344/757 (45%) |
| Insulin treated | 141/341 (41%) |
| Non-insulin treated or diet controlled | 200/341 (59%) |
| Hypertension | 644/755 (85%) |
| BMI, kg/m2 | |
| No. | 754 |
| Median (Q1, Q3) | 29 (26, 33) |
| Obese, BMI ≥30 kg/m2 | 343/754 (45%) |
| eGFR, mL/min/1.73 m2 | |
| No. | 757 |
| Median (Q1, Q3) | 74 (58, 90) |
| eGFR <60 ml/min/1.73 m2 | 206/757 (27%) |
| Baseline dialysis | 49/757 (6%) |
| Left ventricular ejection fraction | |
| No. | 757 |
| Median (Q1, Q3) | 60 (54, 65) |
| Left ventricular ejection fraction <45% | 52/756 (7%) |
| Prior myocardial infarction | 175/754 (23%) |
| Prior PCI | 203/757 (27%) |
| Prior CABG | 43/757 (6%) |
| History of heart failure | 34/757 (4%) |
| History of cerebrovascular disease | 85/756 (11%) |
| History of peripheral artery disease | 45/755 (6%) |
| Family history of premature CAD | 209/645 (32%) |
| Ischemia severity by stress testing | |
| Severe | 329/756 (44%) |
| Moderate | 355/756 (47%) |
| Mild/none | 69/756 (9%) |
| Uninterpretable | 3/756 (0%) |
| CCTA findings | |
| CCTA performed | 508/757 (67%) |
| Any obstructive disease ≥70% stenosis by CCTA | 392/508 (77%) |
| Multivessel disease ≥70% stenosis by CCTA | 185/508 (36%) |
| Vessels ≥70% stenosis by CCTA | |
| 0 | 60/508 (12%) |
| 1 | 134/508 (26%) |
| 2 | 84/508 (17%) |
| 3 or more | 65/508 (13%) |
| Non evaluable | 165/508 (32%) |
a
Continuously measured variables are summarized with the median, 25th percentile (Q1), and 75th percentile (Q3).