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. 2005 Mar 18;4:17. doi: 10.1186/1475-2875-4-17

Table 1.

NADP utilizing enzymes Enzymes are arranged by their sequential functional order. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database and the metabolic function of the enzyme.

Enzyme EC number PfID Peak (HPI) Metabolic function
3-oxoacy1-[acy1-carrier-protein] reductase 1.1.1.100 PFI1125c 28 Fatty acid synthesis
1-deoxy-D-xylulose-5-phosphate reductoisomerase 1.1.1.267 PF14_0641 30 Isoprenoid metabolism
Isocitrate dehydrogenase (NADP+); 1.1.1.42 PF13_0242 28 TCA cycle
Phosphogluconate dehydrogenase 1.1.1.44 PF14_0520 26 PPP
Glucose-6-phosphate 1-dehydrogenase; 1.1.1.49 PF14_0511 48 PPP
Pyruvate dehydrogenase (acetyltransferring). 1.2.4.1 PF11 0256 PF14 0441 28 28 Pyruvate metabolism
Glutamate dehydrogenase (NADP) 1.4.1.4 PF14 0164 PF14 0286 1 30 Glutamate metabolism
Pyrroline-5-carboxylate reductase 1.5.1.2 MAL13P1.284 18 Proline metabolism
Dihydrofolate reductase 1.5.1.3 PFD0830w 26 Folate synthesis
NAD(P)+ transhydrogenase (B-specific); 1.6.1.1 PF14_0508 32 ?
NADPH hemoprotein reductase 1.6.2.4 PFI1140w 13 Flavoprotein reduction
Dihydrolipoamide dehydrogenase 1.8.1.4 PF08 0066 PFL1550w 28 11 Pyruvate metabolism
Dihydrolipoamide S-acetyltransferase; 2.3.1.12 PF10 0407 28 Pyruvate metabolism