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. 2005 Mar 18;4:17. doi: 10.1186/1475-2875-4-17

Table 2.

Enzymes of the pentose phosphate pathway and pyridine nucleotide metabolism. Enzymes are grouped into pathways. They are given by their name, their EC numbers, the gene identification (PfID) in the Plasmodium genome database (PlasmoDB)), the time (in hours post invasion (HPI)) in the parasite's developmental cycle when they are maximally transcribed obtained from the IDC database and the metabolic function of the enzyme.

Pathway Enzyme EC number Pf ID Peak (HPI)
Pentose phosphate pathway Glucose-6-phosphate dehydrogenase 1.1.1.49 PF14_0511 48
6-phosphogluconolactonase 3.1.1.31 PF14 0511 48
6-phosphogluconate dehydrogenase 1.1.1.44 PF14_0520 26
Ribulose 5-phosphate 3-epimerase 5.1.3.1 PFL0960w 29
Ribose 5-phosphate isomerase 5.3.1.6 PFE0730c 21
Transketolase 2.2.1.1 MAL6P1.110 17
Ribose phosphate diphosphokinase 2.7.6.1 PF13 0143 PF13 0157 21 21
Deoxyribose phosphate aldolase 4.1.2.4 PF10 0210 21
Phosphoglucomutase 5.4.2.2 PF10 0122 21

Pyridine nucleotide metabolism Nicotinamidase 3.5.1.19 chr3.glm 243 18, 38
Nicotinatephosphoribosyl transferase 2.4.2.11 chr6.glm_337 25
Nicotinate-nucleotide adenylyl transferase 2.7.7.18 chr13.glm_329 20, 40
NAD+ synthetase 6.3.5.1 PFI1310w 28
Pyridine nucleotide transhydrogenase 1.6.1.1. PF14_0508 32

Thiamine metabolism Hydroxyethylthiazole kinase 2.7.1.50 PFL1920c 22
Hydroxymethylpyrimidine kinase/ Phosphomethylpyrimidine kinase 2.7.149 2.7.4.7 PFE1030c 33
Thiamine-phosphate diphosphorylase 2.5.1.3 MAL6P1.285 1
Thiamine diphosphokinase 2.7.6.2 PFI1195c 28