Table 2.
Inferential statistics for the withdrawal moderation model’s region-of-significance test (arm x timepoint)
| Withdrawal symptoms severity | Odds ratio (OR) | Withdrawal cumulative percentile a | 95% CI | p-value |
|---|---|---|---|---|
| 0 (no symptoms) | 1.30 | 60.46 | 1.01–1.67 | .039 |
| 1 (symptoms present, “not at all severe”) | 1.24 | 60.87 | 0.99–1.56 | .062 |
| 2 | 1.18 | 62.97 | 0.96–1.46 | .119 |
| 3 | 1.13 | 66.47 | 0.92–1.39 | .25 |
| 4 | 1.08 | 70.61 | 0.87–1.33 | .49 |
| 5 | 1.03 | 75.34 | 0.82–1.29 | .81 |
| 6 | 0.98 | 79.25 | 0.77–1.26 | .88 |
| 7 | 0.94 | 83.39 | 0.71–1.24 | .64 |
| 8 | 0.89 | 88.90 | 0.66–1.22 | .48 |
| 9 | 0.85 | 91.49 | 0.60–1.21 | .37 |
| 10 (symptoms present, “very severe”) | 0.81 | 100.00 | 0.55–1.19 | .29 |
a
Empirical cumulative percentiles for withdrawal symptoms severity are provided to clarify the positively skewed distribution of scores. See Figure S4 in the online supplement for probability density plots for withdrawal severity at each time point.