Table 3:

Histologic findings

	Cluster 1	Cluster 2	Cluster 3	Cluster 4	p-value	Post-hoc comparisons
						1 v 2	1 v 3	1 v 4	2 v 3	2 v 4	3 v 4
Fetal findings (loss of nuclear basophilia) – clustering measures
Renal cells
Isolated	1 (0.8)	19 (48.7)	61 (57.5)	0 (0.0)	<0.001	<0.001	<0.001	0.9	0.3	<0.001	<0.001
Majority	1 (0.8)	10 (25.6)	16 (15.1)	106 (94.6)	<0.001	<0.001	<0.001	<0.001	0.14	<0.001	<0.001
Hepatocytes
Isolated	0 (0.0)	38 (97.4)	4 (3.8)	0 (0.0)	<0.001	<0.001	0.045	--	<0.001	<0.001	0.054
Majority	0 (0.0)	38 (97.4)	4 (3.8)	0 (0.0)	<0.001	<0.001	0.045	--	<0.001	<0.001	0.054
Myocytes
Inner	0 (0.0)	15 (38.5)	70 (66.0)	112 (100.0)	<0.001	<0.001	<0.001	<0.001	0.003	<0.001	<0.001
Outer	0 (0.0)	6 (15.4)	65 (61.3)	103 (92.0)	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
Bronchial epithelium	4 (3.3)	5 (12.8)	54 (50.9)	78 (69.6)	<0.001	0.039	<0.001	<0.001	<0.001	<0.001	0.005
GI tract (majority)	1 (0.8)	26 (66.7)	96 (90.6)	109 (97.3)	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.035
Adrenal glands (majority)	3 (2.5)	21 (53.8)	92 (86.8)	108 (96.4)	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001	0.01
Placental findings
Villous karyorrhexis	12 (9.8)	15 (38.5)	34 (32.1)	63 (56.2)	<0.001	<0.001	<0.001	<0.001	0.5	0.05	<0.001
Fetal blood cell karyorrhexis	9 (7.4)	8 (20.5)	21 (19.8)	37 (33.0)	<0.001	0.033	0.006	<0.001	0.9	0.14	0.027
Chorionic vascular lesions	29 (23.8)	17 (43.6)	20 (18.9)	46 (41.1)	<0.001	0.017	0.4	0.005	0.002	0.8	<0.001
Disc calcifications	1 (0.8)	1 (2.6)	4 (3.8)	3 (2.7)	0.5	0.4	0.2	0.4	0.9	0.9	0.7
Umbilical cord
Degenerative changes	7 (5.7)	10 (25.6)	13 (12.3)	22 (19.6)	0.002	0.001	0.082	0.001	0.05	0.4	0.14
Wharton’s substance calcifications	0 (0.0)	0 (0.0)	0 (0.0)	1 (0.9)	0.7	--	--	0.5	--	0.9	0.9

All values given number (percentage of cluster). P-values derived from Chi-Square tests. P-values < 0.05 are considered significant (bolded).