Table 1:
Fold changes in genes upregulated in severe PE (versus normotensive controls) of all three ancestry groups. Listed genes include leading edge genes and genes upregulated at greater or equal to 2.5-fold in African ancestry severe PE placentas. DESeq2 adjusted p value <.05 for all listed genes.
| Leading edge genes | African ancestry fold change | Asian ancestry fold change | European ancestry fold change |
|---|---|---|---|
| LEP | 23.42 | 18.34 | 11.11 |
| FSTL3 | 14.18 | 13.28 | 3.49 |
| HK2 | 6.39 | 5.21 | 3.50 |
| TMEM45A | 4.09 | 2.26 | 3.06 |
| HTRA1 | 3.99 | 2.46 | 2.23 |
| SH3BP5 | 3.69 | 3.07 | 2.39 |
| ENG | 3.59 | 2.36 | 2.27 |
| TPBG | 3.58 | 2.30 | 1.86 |
| INHA | 3.56 | 3.35 | 2.61 |
| NDRG1 | 3.34 | 2.57 | 2.37 |
| SPAG4 | 3.18 | 2.68 | 2.94 |
| SLC6A8 | 2.79 | 2.08 | 2.18 |
| PROCR | 2.59 | 2.09 | 2.35 |
| TRIM14 | 2.58 | 1.87 | 2.03 |
| GAPDH | 2.47 | 1.82 | 1.62 |
| DUSP1 | 2.35 | 1.93 | 1.78 |
| SCARB1 | 1.82 | 1.66 | 1.64 |
| SLC2A1 | 1.79 | 1.71 | 1.61 |
| OCRL | 1.78 | 1.60 | 1.59 |
| RHOB | 1.69 | 1.59 | 1.35 |
| Non-leading edge highly upregulated genes | |||
| ARMS2 | 9.49 | 6.54 | 5.36 |
| ARHGEF4 | 6.09 | 6.31 | 3.02 |
| FLT1 | 5.55 | 4.30 | 4.14 |
| MYO7B | 5.12 | 3.29 | 3.03 |
| PHYHIP | 4.89 | 2.46 | 2.54 |
| CRH | 4.42 | 3.13 | 2.91 |
| QPCT | 4.36 | 2.54 | 2.43 |
| RNF223 | 3.98 | 4.94 | 3.35 |
| PAPPA2 | 3.72 | 4.07 | 2.97 |
| PNCK | 3.37 | 4.24 | 2.89 |
| PLIN2 | 3.29 | 2.32 | 2.09 |
| ARHGAP45 | 3.28 | 3.38 | 2.35 |
| RASEF | 3.21 | 2.32 | 2.29 |
| GPR146 | 3.18 | 1.94 | 1.74 |
| PPP1R3G | 2.86 | 2.34 | 1.57 |
| NPNT | 2.85 | 2.20 | 2.33 |
| MXI1 | 2.79 | 1.95 | 1.70 |
| TET3 | 2.76 | 1.79 | 2.08 |
| NECTIN4 | 2.75 | 2.32 | 1.97 |
| FLNB | 2.72 | 1.75 | 1.77 |
| SASH1 | 2.71 | 2.26 | 2.46 |
| GPT2 | 2.65 | 1.87 | 1.87 |
| HEXB | 2.61 | 1.86 | 1.72 |
| BCL6 | 2.54 | 2.15 | 1.91 |
| SFXN3 | 2.53 | 2.19 | 1.79 |