FIGURE 3.

Liver DNL in relation to NAS components, including fibrosis, as determined by histology, an alternate approach to compare DNL based on the number of NAFLD characteristics present. For example, 11 subjects were found to have steatosis only but no inflammation, ballooning, or fibrosis, whereas 10 subjects were found to have steatosis and inflammation but no ballooning or fibrosis. One-way ANOVA was performed for Liver-TAG amount, as progressive histologic factors were detected in subjects. Four participants that did not fall into any of these categories (had mixed characteristics) were excluded from this analysis. The Liver-TAG 16:0 Fxn DNL for the 4 was 8 ± 4%. Abbreviations: ANOVA, analysis of variance; DNL, de novo lipogenesis; Fxn, fractional; NAFLD, nonalcoholic fatty liver disease; NAS, NAFLD activity score; TAG, triacylglycerol.