TABLE 3.
Changes in plasma protein expression for patients with recurrent spontaneous abortion (RSA) compared with healthy pregnant controls.
| Change | Protein accession number | Protein symbol | Protein description | Fold change |
|---|---|---|---|---|
| Increased | Q9NZT1 | CALML5 | Calmodulin‐like protein 5 | 49.31793 |
| Increased | P20930 | FLG | Filaggrin | 27.97923 |
| Increased | P12277 | CKB | Creatine kinase | 27.06071 |
| Increased | H7BY64 | ZNF511‐PRAP1 | ZNF511‐PRAP1 readthrough (Fragment) | 14.07348 |
| Increased | Q9P232 | CNTN3 | Contactin‐3 | 11.83651 |
| Increased | P08670 | VIM | Vimentin | 10.47412 |
| Increased | Q13885 | TUBB2A | Tubulin beta‐2A chain | 9.372709 |
| Increased | P02741 | CRP | C‐reactive protein | 8.527245 |
| Increased | A0A7I2V599 | HSPD1 | 60 kDa heat shock protein, mitochondrial | 6.465936 |
| Increased | G3V2Y4 | SHMT2 | Glycine hydroxymethyltransferase | 6.406078 |
| Increased | P54886 | ALDH18A1 | Delta‐1‐pyrroline‐5‐carboxylate synthase | 5.820043 |
| Increased | P04818 | TYMS | Thymidylate synthase | 5.018111 |
| Increased | P07900 | HSP90AA1 | Heat shock protein HSP 90‐alpha | 3.942921 |
| Increased | Q9UII2 | ATP5IF1 | ATPase inhibitor, mitochondrial | 3.910618 |
| increased | Q9NY15 | STAB1 | Stabilin‐1 | 3.760155 |
| Increased | P36980 | CFHR2 | Complement factor H‐related protein 2 | 3.257481 |
| Increased | P00338 | LDHA | L‐lactate dehydrogenase A chain | 2.5679 |
| Increased | A0A590UJ50 | CUL1 | Cullin‐1 | 1.93269 |
| Increased | P08709 | F7 | Coagulation factor VII | 1.612481 |
| Increased | Q2KHR2 | RFX7 | DNA‐binding protein RFX7 | 1.610155 |
| Increased | A0A096LPE2 | SAA2‐SAA4 | SAA2‐SAA4 readthrough | 1.585009 |
| Decreased | C9IZG4 | CUTA | Protein CutA | 0.66372 |
| Decreased | Q16853 | AOC3 | Membrane primary amine oxidase | 0.662319 |
| Decreased | Q5TBF5 | OGN | Mimecan (Fragment) | 0.607444 |
| Decreased | O60216 | RAD21 | Double‐strand‐break repair protein rad21 homolog | 0.600058 |
| Decreased | A2NJV5 | IGKV2‐29 | Immunoglobulin kappa variable 2–29 | 0.597405 |
| Decreased | Q99784 | OLFM1 | Noelin | 0.573918 |
| Decreased | H0YCV9 | CD44 | CD44 antigen (Fragment) | 0.553145 |
| Decreased | Q12860 | CNTN1 | Contactin‐1 | 0.545997 |
| Decreased | P01602 | IGKV1‐5 | Immunoglobulin kappa variable 1–5 | 0.529698 |
| Decreased | Q6YHK3 | CD109 | CD109 antigen | 0.525126 |
| Decreased | Q6UXB8 | PI16 | Peptidase inhibitor 16 | 0.470647 |
| Decreased | Q16777 | H2AC20 | Histone H2A type 2‐C | 0.45164 |
| Decreased | P01871 | IGHM | Immunoglobulin heavy constant mu | 0.395486 |
| Decreased | Q9UFW8 | CGGBP1 | CGG triplet repeat‐binding protein 1 | 0.38565 |
| Decreased | P18065 | IGFBP2 | Insulin‐like growth factor‐binding protein 2 | 0.274695 |
| Decreased | H9KV31 | NCAM2 | Neural cell adhesion molecule 2 | 0.233204 |
| Decreased | P35754 | GLRX | Glutaredoxin‐1 | 0.233043 |
| Decreased | Q8WWA0 | ITLN1 | Intelectin‐1 | 0.228822 |
| Decreased | J3KR24 | IARS1 | Isoleucine–tRNA ligase | 0.17517 |
| Decreased | P48426 | PIP4K2A | Phosphatidylinositol 5‐phosphate 4‐kinase type‐2 alpha | 0.174058 |
| Decreased | P31948 | STIP1 | Stress‐induced‐phosphoprotein 1 | 0.159402 |
| Decreased | O00566 | MPHOSPH10 | U3 small nucleolar ribonucleoprotein protein MPP10 | 0.153884 |
| Decreased | A0A7P0Z4D3 | TNPO1 | Transportin‐1 | 0.131655 |
| Decreased | Q9Y6X0 | SETBP1 | SET‐binding protein | 0.12996 |
| Decreased | E7ETR0 | RUVBL1 | RuvB‐like helicase | 0.128957 |
| Decreased | H7C463 | IMMT | MICOS complex subunit MIC60 | 0.1191 |
| Decreased | H0YN14 | IPO4 | Importin‐4 | 0.118492 |
| Decreased | P00441 | SOD1 | Superoxide dismutase [Cu‐Zn] | 0.11709 |
| Decreased | P01718 | IGLV3‐27 | Immunoglobulin lambda variable 3–27 | 0.098263 |
| Decreased | Q9Y2W1 | THRAP3 | Thyroid hormone receptor‐associated protein 3 | 0.09706 |
| Decreased | Q9HBR0 | SLC38A10 | Putative sodium‐coupled neutral amino acid transporter 10 | 0.096692 |
| Decreased | A0A0C4DH38 | IGHV5‐51 | Immunoglobulin heavy variable 5–51 | 0.083607 |
| Decreased | A0A0B4J1U7 | IGHV6‐1 | Immunoglobulin heavy variable 6–1 | 0.083014 |
| Decreased | Q13449 | LSAMP | Limbic system‐associated membrane protein | 0.077074 |
| Decreased | Q05639 | EEF1A2 | Elongation factor 1‐alpha 2 | 0.030081 |
| Decreased | P62841 | RPS15 | 40S ribosomal protein S15 | 0.007854 |
Note: Fold change is the ratio of the protein concentrations between the samples collected from healthy pregnant controls and from patients with RSA.