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. Author manuscript; available in PMC: 2024 Nov 1.
Published in final edited form as: Leukemia. 2023 Sep 5;37(11):2261–2275. doi: 10.1038/s41375-023-02014-8

Fig. 6. MiR-9-1 regulates the expression of the genes associated with osteoblastic differentiation and function in MSCs.

Fig. 6

MSCs (Lin−CD45−CD31−CD51+Sca-1+) were sorted from growth-retarded miR-9-1−/− and wild-type control mice and directly subjected to RNA-seq. A Heatmap of differentially expressed genes between miR-9-1−/− and control MSCs. Genes with an adjusted p-value < 0.05 found by DESeq2 were assigned as differentially expressed. B Heatmap of differentially expressed osteoblast-specific, extracellular organization and cell adhesion molecule genes in miR-9-1−/− relative control MSCs. C GSEA plots of osteoblast differentiation gene signatures in miR-9-1−/− and control MSCs. D GO enrichment analysis of downregulated genes in miR-9-1−/− relative to control MSCs. Bar plots show negative log10 of p-values for GO enrichment analysis of the biological pathways in control relative to miR-9-1−/− MSCs. Data shown is obtained from 4 growth-retarded miR-9-1−/− and wild-type mice.