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. 2024 Jan 6;38(2):372–382. doi: 10.1038/s41375-023-02129-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Distribution of CAR and non-CAR CD4⁺ (top) as well as CD8⁺ (bottom) T cells in PB of non-PD and PD patients 7, 14, and 30 days after CAR T cell infusion. B Proportions of naïve (CD45RA⁺CD45RO^-CCR7⁺), central memory (CD45RA^-CD45RO⁺CCR7⁺), effector memory (CD45RA^-CD45RO⁺CCR7^-), and effector (CD45RA⁺CD45RO^-CCR7^-) CD4⁺ (top) as well as CD8⁺ (bottom) T cells in PB of non-PD and PD patients at day of leukapheresis and 7, 14, 30, and 100 days after CAR T cell infusion. C Percentages of CD25⁺CD127^low Treg cells as well as D PD-1⁺ cells within CD3⁺ T cell compartment in PB of non-PD and PD patients on day of leukapheresis (D) and on days 0, 7, 14, 30, and 100 (C, D). Mann–Whitney U test was performed to calculate significances between A CAR and non-CAR T cells, B non-PD and PD patients, C day 0 and days after CAR T cell infusion (7, 14, 30, and 100) and D day of leukapheresis (LA) and days 0, 7, 14, 30 and 100. *p < 0.05, **p < 0.01, ***p < 0.001, ns not significant.