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. 2023 Nov 27;38(2):340–350. doi: 10.1038/s41375-023-02093-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A UMAP plots of non-malignant LN T cell subclusters. Cells are shown separately for each clinical status (right panels). T_CM, central memory T cell; T_DYS, dysfunctional T cell; T_EFF, effector T cell; T_N, naïve T cell; T_PRO, proliferative T cell; T_PRO/DYS, proliferative dysfunctional T cell; T_REG, regulatory T cell. B Comparison of proportions of each cluster in non-malignant MNCs per sample. The boxplots show the median (center line), interquartile range (box limits), minimum to max values (whiskers), and samples (dots) for each group. P values are shown only for significant differences. *P < 5.0 × 10⁻². C Clone size (i) and overlap analysis (ii) of TCRs in non-malignant LN T cells. The number of cells expressing each clonotype was defined as clone size and illustrated for each cell. The “repOverlap” function of Immunarch measured the TCR sharing between each cluster, analyzed and illustrated for TFHL LNs (upper right) and HLNs (lower left), respectively.