Table 2.
Effects of targeted clearance of senescent cell on renal outcomes in renal models.
| Animals | Renal model | Methods for clearing senescent cell | Evidence of senescent cell clearance | Renal outcome | Reference |
|---|---|---|---|---|---|
| INK-ATTAC mice | Natural aging | AP20187 administration to deplete p16- positive cells | SA-β-gal positivity ↓ |
Glomerulosclerosis ↓ Blood urea nitrogen levels ↓ |
[50] |
| INK-ATTAC mice | Renal artery stenosis-induced ischemic Nephropathy | AP20187 administration to deplete p16- positive cells |
SA-β-gal positivity ↓ P16 positivity ↓ SASP (IL1a, IL6, Ccl2, Mmp3, TNF-a) ↓ |
Interstitial fibrosis ↓ Renal perfusion ↑ |
[163] |
| XpdTTD/TTD Mice | Fast-aging | FOXO4-DRI induces targeted apoptosis of senescent cells |
Lamin B1 ↑ SASP (IL1a, IL1β, IL6) ↓ |
Serum urea ↓ Serum creatinine ↓ |
[170] |
| p16-3MR | Natural-aging | Ganciclovir induces p16-positive-restricted cell apoptosis |
Lamin B1 ↑ SASP (IL6) ↓ |
Serum urea ↓ Serum creatinine ↓ |
[170] |
| p16-3MR | Folic acid-induced AKI | Ganciclovir induces p16-positive senescent cell apoptosis |
SA-β-gal positivity ↓ Lamin B1↑ Ki-67 ↑ |
Interstitial fibrosis ↓ No effects on tubular damage |
[133] |
| Wild-type mice (C57BL/6J) | Folic acid-induced AKI | FOXO4-DRI induces apoptosis of senescent cells |
SA-β-gal positivity ↓ Lamin B1↑ Ki-67 ↑ |
No effects on kidney damage and interstitial fibrosis | [133] |