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. 2024 Feb 5;15:1051. doi: 10.1038/s41467-024-45171-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Neutralization curves of 17T2 mAb against HIV-1 based pseudoviruses expressing the indicated SARS-CoV-2 spike variants. Duplicate values corresponding to a representative experiment out of two are shown. b Heatmap showing the neutralization activity as IC₅₀ values of the selected mAbs against the indicated SARS-CoV-2 pseudoviruses. Values are in ng/mL, darker color corresponds to higher potency as indicated in the bottom of the Figure. c Neutralization curves of 17T2 (red), S309 (gray) and S2E12 (blue) mAbs against the indicated SARS-CoV-2 variants or SARS-CoV-1 (all exposed on the surface of HIV-1 based pseudoviruses). Duplicate values corresponding to a representative experiment out of at least two are shown. d Heatmap showing IC₅₀ values from panel C in ng/mL. As in (b), darker color corresponds to higher potency as indicated in the bottom of the Figure. e Impact of Omicron subvariants on pseudovirus neutralization capacity. IC₅₀ values for pre-Omicron variants (WH1, D614G, Alpha, Beta, Gamma, and Delta) were grouped (n = 6) and compared to Omicron subvariants (BA.1, BA.2, BA.4/5, BQ.1.1, XBB.1.5, XBB.1.16, EG.5.1 and BA.2.86; n = 8). Solid bars show the geometric mean. P values show individual corrected comparisons for each antibody using two-sided Kruskal-Wallis test with a global p value of <0.0001. Source data are provided as a Source Data file.