Figure 5.
Early increase in abundance of taxa Verrucomicrobiota following CCI. (A) The phylum Verrucomicrobiota is differentially abundant in CCI animals compared to time-matched sham animals at 1, 2, and 3 d post-injury using ANCOM-BC. A log-fold change value (y-axis) of 0 indicates equivalent taxa abundance while above 0 indicates increased abundance in sham mice, and a log-fold change value below 0 indicates that a taxa is more abundant in CCI animals. (B) This taxa is differentially abundant down to an order level (Verrucomicrobiales) in CCI animals compared to time-matched sham animals at 2 and 3 d post-injury. Data are represented as log-fold change and standard error (## q < 0.01). (C) The Verrucomicrobiota species Akkermansia muciniphila is increased at 2 and 3 d post-injury as determined by qPCR. Data are represented as mean and standard deviation (*p < 0.05; nsham = 6, nCCI = 7).