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. 2024 Feb 5;14:2990. doi: 10.1038/s41598-024-53430-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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CCI induces colon hypoxia at 3 d post-injury. Representative images of hypoxyprobe-1 staining (HP1, red) in the colon of (A) sham and (B) 3 d post-CCI mice. (C) Traces of hypoxia intensity as a function of distance from the lumen, averaged from three crypts within three randomly selected fields of view from sham (blue), 1 d CCI (red), and 3 d CCI (black). (D) Area under the hypoxia intensity curve is increased at 3 d post-CCI compared to sham mice. (E) Peak hypoxia is also increased at 3 d post-CCI. Whiskers represent minimum and maximum, box represents 25th–75th percentile, and line represents median value (*p < 0.05; n_sham = 11, n_CCI = 6–7/timepoint).