FIGURE 10.

Differential expression of the glucocorticoid receptor Nr3c1 by genotype and stress exposure in pituitary, colon, and liver. We compared Nr3c1 expression between wild-type (WT, black) and Krtcap3 knock-out (KO, gray) control rats (filled) and exposed to stress (empty) in multiple tissues. (A) Stress-exposed KO rats had greater pituitary Nr3c1 expression than control counterparts, with no significant difference in WT rats. *p < 0.05 represents effect of stress for KO rats. (B) In the colon, control KO rats had greater Nr3c1 expression than control WT and greater expression than stress-exposed KO rats. ^# p < 0.1 represents effect of stress for KO rats, *p < 0.05 represents effect of genotype for control rats. (C) In the liver control WT rats had lower Nr3c1 expression than control KO rats and stress-exposed WT rats. Stress exposure did not alter expression in KO rats. *p < 0.05 represents effect of stress for WT rats and effect of genotype for control rats.