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. 2024 Jan 23;14:1247232. doi: 10.3389/fgene.2023.1247232

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Copyright © 2024 Szalanczy, Fitzpatrick, Beeson, Bui, Dyson, Eller, Landry, Scott, Grzybowski, Klotz, Geurts, Weiner, Redei and Solberg Woods.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forced swim test indicates that stress exposure more greatly alters stress coping in Krtcap3 knock-out (KO, gray) rats compared to wild-type (WT, black) rats. The FST is a 2-day test: Day 1 is a 15-min training swim while Day 2 is a 5-min test swim. (A) When compared to control rats (filled), stress-exposed rats (empty) of both genotypes had increased immobility and (B) decreased mobility compared to control rats (filled) on Day 2 of the test. **p < 0.01 represents a main effect of stress. (C) The change in immobility from Day 1 to Day 2 was significantly greater in control rats compared to stress-exposed rats, regardless of genotype. However, within the stress-exposed rats, immobility did not change in WT rats but had continued to increase between the days in KO rats, indicating differences in the stress coping response. **p < 0.01 represents effect of genotype respective to stress exposure; ****p < 0.0001 represents a main effect of stress.